Clavacin, an Antibiotic Substance from Aspergillus Clavatus*
نویسندگان
چکیده
In 1942 Wiesner (1) and Waksman, Horning, and Spencer (2) demonstrated that filtrates from cultures of Aspergillus clavatus grown upon synthetic media possess antibiotic activity. These investigators extracted and partially purified the active material (which was named clavacin by Waksman) but did not report its isolation in pure form. As a result of the observations made by Waksman’s group, particularly those on the antibiotic activity toward Gram-negative organisms, we became interested in this antibiotic substance and undertook the investigat,ions of it as part of our work under Contract OEMcmr-155. In the latter part of last year, Raistrick et al. (3) published a report on the isolation and characterization of patulin, an antibiotic substance produced by Penidium pat&urn Bainier and, furthermore, showed that the same compound is produced by P. expansum (4). Subsequent to Raistrick’s first report, Bergel et aE. (5) and Hooper et al. (6) announced the isolation of a crystalline compound from Aspergillus elavatus which on the basis of the data submitted appears to be identical with patulin. Furthermore, Florey, Jennings, and Philpot (7) showed that the same compound is produced by A. giganteus Wehm, and Bergel et al. (5) and Chain, Florey, and Jennings (8) showed that the compound, claviformin, which the latter had previously isolated from P. cZuvij”orme in 1942 (9) is likewise identical with patulin. Although we had isolated a crystalline antibiotic from A. clavatus and prepared the semicarbazone, thiosemicarbazone, 2,4-dinitrophenylhydrazone, and oxime derivatives and a catalytic reduction product
منابع مشابه
Two Antagonistic Fungi, Aspergillus fumigatus and Aspergillus clavatus, and Their Antibiotic Substances.
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